The history of phytotherapy began with the history of mankind. Animals and people try to find edible and medicinal plants through trial and error. This process can be regarded as natural and very long pharmacological experiment, which the targeted study of the healing properties of plants and methods of their application has come to replace. Information of medicinal herbals transmitted orally from generation to generation, and later observations were recorded on clay tiles, papyri and in the books. The earliest written evidence of phototherapy is the clay tablets with records of plants and diseases found in Assyria. About the medicinal properties of plants are mentioned in the monuments of other ancient cultures: Sanskrit, Egyptian, Chinese, Greek, and Roman. The Egyptians even 4000 years BC have a description of medicinal plants in Egypt - like pharmacopoeia. One of the extant evidence of this is George Ebers Papyrus, named after its discoverer. This document, dating back to 1570 BC, contains information about diseases and how to treat them. The structure described of drugs in the Papyrus included such plants as onions, pomegranate, aloe vera, grapes, dates, poppy and others. The founder of the European phytotherapy became Roman scientist Dioscorides (I century BC). Start of production of extractive products (teas, tinctures) put the Roman physician Claudius Galen. European pharmacy was established by the Arab sample, and at first used mainly imported Arab materials. Medieval European herbalists were mainly compilations from the writings of Dioscorides and Galen. These herbalists were the real key to healing and health. There was Oriental School of Medicine, first of all, the Indian and the associated Tibetan. The oldest written monument with a description of medicinal plants in India and how they use is the Yajur-veda (science of life), which refers to the first century BC. Some Indian plants, such chilibuha and Rauwolfia, entered into European medical practice. The first Chinese book about herbs appeared in 2600 BC. It describes 900 species of medicinal plants. Number of medicinal plants known to doctors, has grown thanks to the great geographical discoveries. So in the arsenal of healers included bark cinchona tree is an American plant. It was the only remedy against malaria for a long time. The use of herbals is based on empirical observation. Only at the end of the XVIII century Swedish chemist K. Scheele developed the first methods of chemical analysis of plants that evolved in the XIX and XX centuries.